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Axial and sagittal proton density and T2-weighted MR images(TR 2,500-3,000 ms,TE 15-22 and 85-90 ms)were performed in 50 patients with multiple sclerosis(MS)on a 1.5 T superconductive system.The number of plaques on the axial and sagittal images in the periventricular white matter,the corpus,callosum,the brain stem,and cerebellum,and the basal ganglia were counted separately by two independent observers.A total of 858 lesions (mean 17.40+or-21.57)were seen on the axial series and 1,196(mean 24.32+ or-26.22)on the sagittal scan.More lesions were visualized in the periventricular region(mean 18.79+or-21.69 versus 13.34+or-16.45;p<0.001) and the corpus callosum(mean 3.00+or-2.72 versus 0.57+or-1.19;p<0.001).In the brain stem more lesions were visualized on the axial images(mean 1.55+ or-2.55 versus 0.87+or-1.20;p<0.05).In the cerebellum and basal ganglia, scans in the two planes were equivalent(p>0.5).In three patients lesions were seen on the sagittal series,while the axial scans were normal. Sagittal T2-weighted images appear to demonstrate significantly more MS plaques than transverse images,especially in periventricular region and the corpus callosum.This is explained by partial volume averaging,by the orientation of some cerebral structures(e.g.corpus callosum)with regard to the section plane,and by the longer diameter of the lesions in the axial plane. |
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corpus callosum
corpus callosum,atrophy of
corpus callosum,lesion of
MRI
MRI,abnormal
MRI,demyelinating disease
MRI,false negative
multiple sclerosis
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